|Hydratime® Day cream and Nutritime® night cream combined, are a derma-cosmetic management system particularly effective for dry, itchy, irritated skin conditions due to its superb upper skin hydration.
They nourish deeply by providing the complete range of ceramides in combination with other functional ingredients which support skin lipid density. Hydration is achieved by the activity of Hyaluronic Acid and Saccharide Isomerate enhancing moisture levels.
Hydratime® and Nutritime® sustain, protect and re-establish the skin's barrier properties. They provide sun protection, antioxidant, anti-inflammatory and antibacterial agents. Absorbable forms of Vitamins C and E combine to calm irritated itchy dry skin.
Ceramide boosting is so much more than moisturising. Many dry skins, oily skin and many skin problems such as eczema, ichthyosis, psoriasis, rosacea and also acne can all benefit from ceramide supplementation.
- Trans Epidermal Water Loss (TEWL) control is critical for healthy skin.
- Water is always travelling out of the skin and there are various structures and processes in place to control the rate of TEWL.
- The membranes of skin cells and the oils produced by the skin have an important role to play in maintaining skin cell integrity (life) and influencing the ageing process.
- Lipids are a critical component in maintaining the structural shape and moisture retaining the functionality of the skin. They are also important in controlling the rate of TEWL.
- Over time or through heredity situations often triggered or exacerbated by environmental challenges and often influenced by hormonal changes, life changes and medication, the skin can become lipid deficient.
- Supplementing lipids in the skin so new skin cells are made with a high lipid density is essential for any anti-ageing regimen.
- Ceramides and natural ingredients that release ceramides can be used by the skin to produce more lipid dense tissue.
- Many skin conditions lead to TEWL being compromised and many can be ameliorated by addressing TEWL.
What are Ceramides?
- Ceramides are a family of lipid molecules found in high concentrations within the cell membrane of cells.
- They are one of the component lipids that make up sphingomyelin, one of the major lipids in the cell wall lipid bilayer.
- It was assumed that ceramides and other sphingolipids found in the bilayer cell membrane were purely structural elements.
- It is now known ceramides can actually act as signalling molecules as well.
- The most well-known functions of ceramides as cellular signals include regulating the differentiation, proliferation, apoptosis of cells and programmed cell death.
- The top layer of the epidermis is the Stratum Corneum (SC). Even though the SC is very thin (10-30 micro-metres); it is the main barrier of the skin. It keeps chemicals contacting the skin from absorbing into the body, and it keeps water inside the skin.
- The stratum corneum contains three types of lipids -- ceramides, cholesterol and free fatty acids. These lipids have different chemical compositions and functions. There are nine different types of ceramides in the SC, conveniently named ceramide 1 through to ceramide 9, and they account for 40 to 50% of the lipids in this outermost layer.
Ceramides and Skin Disease
- Eczema sufferers have significantly fewer ceramides in their Stratum Corneum.
- Psoriasis sufferers, in contrast, have the same number of ceramides compared to people with normal skin. However, the psoriasis sufferers have less ceramide 1, 3, 4, and a subset of 5 and 6; and more ceramide 2 and another subset of 5.
- Replacing Ceramides improves eczema. Recent studies have shown that lipids can be replaced with topical preparations.
- Interestingly, all three lipids have to be replaced at a certain ratio to restore the barrier function of the skin. If the incorrect balance of lipids is applied, it actually takes longer for the skin to heal. The effect of ceramides has been studied in eczema, but there are also interesting outcomes being seen with psoriasis management.
- Trans Epidermal Water Loss happens in everyone but is usually abnormal and excessive in people with skin issues , ageing skin, sun damaged skin, and many skin conditions ranging from acne, eczema , psoriasis, ichthyosis.
- Ceramides play an important part in controlling cellular water loss and skin water loss. Water loss leads to dehydration. Dehydration impairs cellular function, cell communication and increases cell stress and can hasten cell death.
- Skin can respond to dehydration by increasing skin lipid content to compensate, but in some this response is impaired and instead the skin can crack and dry. In other situations/types who have or develop a lipid and ceramide deficiency, liquid oil (sebum) production is increased, skin cell production increases to thicken the skin and increased keratin production creates an increased barrier to water loss (the horny layer). As the stratum corneum also lines the neck of the hair follicle duct, then as it thickens here, this leads to a closure (blocking) of the duct and then the development of blackheads and then through bacterial colonisation of the blocked duct; acne.
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